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As a crucial signaling molecule, RA exerts its biological effects by binding to the nuclear receptors RAR/RXR, thereby regulating downstream gene expression networks that govern critical cellular processes, including differentiation, proliferation, and fate determination (Figure 1, studies have revealed distinct expression patterns of ALDH1A1 and ALDH1A3 in prostate cancer tissues that correlate with clinical outcomes

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doi: 10.1126/science.1260419 171 KachayloEMPustylnyakVOLyakhovichVVGulyaevaLF

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