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Lab assays typically measure both endogenous IGF-1 and exogenous LR3 IGF-1, so on-cycle values can be misleading

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31, 32, 34, 36, 51, 122, 123 HDL exerts anti-inflammatory effects on all cell types relevant to atherosclerosis, which has been detailed in recent reviews

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These studies suggest that EDCs exposure affects the expression of GnRH and kisspeptin, influences the pulsatile launch of GnRH, and interferes with the regulation of gonadotropin production from the pituitary axis (63)