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Excluding patients who received nelarabine (AALL0434) or bortezomib (AALL1231), the 4-year EFS ( P = .412), OS ( P = .600), cumulative incidence of CNS relapse ( P = .456), and overall relapse ( P = .836) rates were not significantly different between the studies, indicating that the omission of cranial radiation (in the context of the AALL1231 chemotherapy backbone) did not adversely impact outcome

The Importance of Antioxidants Antioxidants are substances that protect our cells from oxidative stressa condition caused by an imbalance between free radicals and antioxidants in the body

As expected, the highest decrease was shown for the controlled fermentation (FF) and an opposite trend was shown by TTA (Table 1)

10.1038/s41586-019-1707-0 32 DolmaS.LessnickS