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PRDX1, a target gene of NRF2, plays a critical role in maintaining redox balance, and its decline is associated with age-related changes in the cornea [123]

6C,D), which might be due to the compensatory effects of GSH

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The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light