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Apoptosis of alveolar type II epithelial cells was also observed in bleomycin- or thoracic irradiation-treated mice (98, 99)

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doi: 10.1111/bjh.12154 57

Incidence of nasal tumours in Wistar rats after 28 months of exposure a,b Types of tumour 0 1350 2700 2760 c mg/m 3 mg/m 3 mg/m 3 mg/m 3 Males Squamous cell carcinoma 1/49 1/52 10/53* 16/49*** Adenocarcinoma 0/49 16/52*** 31/53*** 21/49*** Carcinoma in situ 0/49 0/52 0/53 1/49 Females Squamous cell carcinoma 0/50 0/48 5/53 17/53*** Adenocarcinoma 0/50 6/48* 28/53*** 23/53*** Carcinoma in situ 0/50 0/48 3/53 5/53 a From: Woutersen et al

This three helix bundle domain has been used as a scaffold for the construction of combinatorial phagemid libraries, from which affibody variants that target the desired molecules can be selected using phage display technology see, e.g,