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If the kidneys are already under strain (which is common with age, diabetes, or high blood pressure), this direct load can be too much to handle

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Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

[DOI] [PMC free article] [PubMed] [Google Scholar] 195.Chen Y, Zhang L, Zhang Y, Bai T, Song J, Qian W, Hou X

The combination of isatuximab-Kd was further investigated in the Phase III IKEMA trial, a randomized, open-label study conducted across 16 countries in North America, South America, Europe, and the AsiaPacific region [54, 64]
