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Low disease severity and/or inadequate disease penetrance are both associated with high mtDNAcn in mitochondrial disorders [6], and lower metabolic plasticity corresponds with the observed decrease in mtDNAcn [38]

Consult your physician before beginning any new prescription treatment

While natural presence in the body is reassuring, supplementation introduces higher concentrations than the body typically manages, which can occasionally lead to side effects, particularly in vulnerable populations or when combined with certain medications

doi: 10.1074/jbc.274.10.6366

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