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Transcription factors with the most connections to other genes included EPAS1 (also known as HIF-2), KLF13, TAL1, TBX3, GATA2, and BCL11A (Additional file 4)

In a study by Zhao et al., 2022, diabetic patients receiving 4000 IU/day of Vitamin D3 showed a 35% reduction in inflammatory markers like IL-6 and TNF-, alongside a 10% improvement in insulin sensitivity [65]

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For example, egl-9 mutants show decreased rates of locomotion and defecation and increased resistance to various stressors, including hypoxia and oxidative stress 18,29,30

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