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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA)

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Goerner A, Reichstein M, Tomelleri E, Hanan N, Rambal S, Papale D, Dragoni D, Schmullius C
