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This disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta that project to the striatum (Samii et al., 2004), and the early accumulation of -synuclein deposits in the cholinergic neurons of the basal forebrain

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about the width of a quarter

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The second occurs between the carboxyl group of Tyr100 and the oxygen of the phenolic group of curcumin (1.80)

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