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1,2 However, the metabolic and performance benefits remain uncertain, with one study showing an increased work output over 30 min all out performance test at 24 weeks supplementation (but no increase at 12 weeks 1 ) while Shannon et al
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TMAO also induces endothelial dysfunction by disrupting junction proteins, activating the NLRP3 inflammasome to release high-mobility group box 1 protein (HMGB1), and altering endothelial permeability (Singh et al., 2019)
Main features Its main role is to transport long-chain fatty acids to muscle cells
