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PLoS ONE 6 , e16199 (2011)

Lei D, Sturgis EM, Liu Z, Zafereo ME , Wei Q, Li G

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Furthermore, a separate study confirmed the involvement of ferroptosis in the pathogenesis of epilepsy associated with mitochondrial disease and revealed that alpha-tocotrienol quinone (EPI-743) effectively ameliorated ferroptosis in cells derived from patients with five distinct childhood epilepsy syndromes in a dose-dependent manner by reducing lipid peroxidation (LPO) and 15-hydroxyditetraenoic acid (15-HETE) levels (17)