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Inhibition of ACSL4 expression or knockdown of LPCAT3 may be key mechanisms for ultimately regulating ferroptosis through different signaling pathways

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In LLD, vitamin B1 deficiency can impair TCA cycle function, leading to disrupted energy metabolism in emotion-regulating brain regions such as the hippocampus and prefrontal cortex (37)

Targeting SIRT1 rescues age- and obesity-induced microvascular dysfunction in ex vivo human vessels

It catalyzes the sequence of (i) H 2 O 2 -dependent oxidative reactions of iodide oxidation to an iodonium intermediate, followed by (ii) the iodination of selected tyrosyl-residues of TG, the protein enabling synthesis, storage and secretion of TH, and finally, the coupling of selected diiodo-tyrosine (DIT) residues of TG to T4, or of one DIT and one monoiodo-tyrosine (MIT) to T3