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If we look at different studies, however, we can see that injecting hydroxocobalamin has not been proven to be more effective in treating B12 deficiency than ingesting oral tablets available over the counter

McCandless SE, Yanovski JA, Miller J, Fu C, Bird LM, Salehi P, et al

These studies show that improving tumor vessel perfusion and oxygenation ameliorates the efficacy of conventional therapies such as radiotherapy, chemotherapy and immunotherapy and reduces metastatic dissemination [309, 310]

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In this study however, the weight loss efficacy and tolerability profile of davalintide was not superior to pramlintide, and was inferior to the pramlintide/metreleptin combination, thus resulting in deciding to halt further development of davalintide