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one only observes pericentral and periportal LSEC populations after Day 56 in rodents 42 , equivalent to many months to years in humans

Physiol Res 65(4):547560 Talbert EE, Smuder AJ, Min K, Kwon OS, Powers SK (2013) Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy

J Leukoc Biol 77:598625

They prevent loss of membrane and the resultant decrease in the surface areatovolume ratio of the RBC

Therefore, studies investigating the activity and toxicity of LD in depth are still needed
doi: 10.18632/oncotarget.20278
