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Based on the hypothesis that free copper leads to disease manifestation, we selected appropriate publications addressing this topic over the last 50 years

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BVR-A is a direct target of the IR kinase activity, and as part of a regulatory loop BVR-A phosphorylates IRS1 on inhibitory Ser residues to prevent IRS1 aberrant activation in response to IR

Sig Transduct Target Ther 8 , 352 (2023)

Copper is mainly absorbed in the intestine by ATP7A (a member of the P-type ATPase family, it shares a similar structure and function with ATP7B and is mainly expressed in the intestinal epithelium.) [33], and is delivered to the hepatocyte by HCTR1 (a high-affinity copper transport protein) [34]