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Reconstituted FOXO4-DRI remains biologically active for 28 days when refrigerated at 28C, but efficacy declines measurably after day 14 even under ideal storage conditions

Subsequently, tyrosines 1349 and 1356 in the carboxy-terminal tail become phosphorylated

Classification of oxidative stress based on its intensity

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Community oral protocols are typically once daily

Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritis