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Additionally, Nrf2 overactivation in hepatoma cells inhibits the pro-inflammatory response by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, creating a favorable environment for malignant cell survival and protecting them from oxidative stress [138]

The introduction of antipsychotics in the 1950s revolutionized the treatment of schizophrenia, providing a particularly effective therapy for managing the positive symptoms of the disease (119)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Matherly L.H., Hou Z

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The heterogeneity of clinical and behavioral features in children diagnosed with ASD contributes to the difficulty in understanding the pathophysiology of this disorder, and consequently, no specific treatment can be effective for all ASD children