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Furthermore, NADPH pools are compartmentalized in various organelles with no known membrane transporters, suggesting that NADPH-dependent pathways are regulated in an organelle-specific manner

Although WT -GCS-GS is nearly uninhibited by GSH (Ki 140 mM), shorter -GCS domain constructs were unexpectedly found to be strongly inhibited (Ki 15 mM), reproducing a physiologically important regulation seen in monofunctional -GCS enzymes