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Given these biological and methodological constraints, the field is increasingly turning toward multimodal strategies to capture the complexity of neuroprotection

Among ACSLs, acyl-CoA synthetase long-chain family member 4 (ACSL4) is the first one identified promoting lipid peroxidation [41]

Additionally, there are under-investigation oral PCSK9 inhibitors (e.g., macrocyclic peptide MK-0616) [1114]

Inhibition of the CD47-SIRP signaling axis using agents like RRx-001 can further potentiate necroptosis by disabling the dont eat me signal, thereby enhancing tumor cell clearance [17]

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