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The basic strategy is to obtain a reagent focusing its activity prevalently around the cells expressing CD38, which enables avidity-induced blocking of CD47 on the same cells, in this way avoiding unwanted off-tumor effects

Smaller peptides have some resilience against rough handling

Have you had a homocysteine blood test and a methylmalonic acid - MMA - that would show whether you were low at cellular level

Baseline Hcy appears to be a better predictive marker than MMA for haematological toxicity

TRP, transient receptor potential