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Additionally, esculin (20-40 mg/kg) can inhibit the TLR4/MyD88/NF-B signaling pathway and downregulate the expression of TNF-, IL-1 and IL-6 in LPS-induced acute lung injury mice (103)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [85].Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, et al

While many people take vitamin C for general wellness or to help shorten the duration of colds, research also highlights its role in cardiovascular health, skin repair and the neutralisation of free radicals that contribute to cellular ageing

129 Hypoxia initiates the unfolded protein response or UPR, which can in turn induce autophagy through ATF4 (activating transcription factor 4) activation

Data analysis was performed using FlowJo v10.9 (BD Biosciences)