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Phase II clinical trials in patients with sarcoidosis-related small fiber neuropathy demonstrated significant increases in corneal nerve fiber density (a reliable surrogate marker for systemic small fiber health) alongside meaningful reductions in neuropathic pain scores

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14,22 Dysbiosis, or imbalance in the composition and/or function of this microbial community, has been strongly associated with GI diseases 6 as well as systemic conditions via its influence on other organs through the numerous gut-organ axesemphasizing the gut's interconnectedness with broader health processes

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