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During Phase I and Phase II liver detoxification, glutathione plays a pivotal role in transforming harmful substances into water-soluble compounds that can be easily excreted

Conversely, TXNIP positively regulates ferroptosis across various diseases, including diabetic retinopathy, high-fructose-induced nephropathy, sarcopenia and ex vivo liver transplantation models, and serves as a ferroptosis-related gene for cancer diagnosis and prognosis prediction

However, oxidized forms of glutathione, such as cysteine-glutathione disulfide, and 4-hydroxy-nonenal-glutathione (GS-HNE), were higher in senescent than control fibroblasts both in replicative and oncogene-induced senescence (Quijano et al., 2012