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We mutated all eight lysine (K) to arginine (R), mimicking the delactylation of protein

We identify a compound that degrades MYC, A80.2HCl, which induces MYC degradation at nanomolar concentrations, restores pRB1 protein levels and re-establish sensitivity of MYC high-expressing cancer cells to CDK4/6i

Non-treated cells were used as a negative control

doi: 10.1038/s41598-023-47229-y

Prevalence and Predictors of Premature Graying of Hair Before the Age of 30: A Cross-Sectional Study in Saudi Arabia

The biosynthesis capacity of cells is usually overloaded by the forced expression of a recombinant protein, which leads to the adverse response known as metabolic burden (Oh and Liao, 2000)