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[39] By differential scanning calorimetry (DSC), holo SOD1 unfolds by a two-state mechanism: from dimer to two unfolded monomers

doi:10.1016/j.yhbeh.2015.06.020 Movsas TZ, Weiner RL, Greenberg MB, Holtzman DM, Galindo R

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Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

Cereblon-based PROTAC 26 (DYR684) induced rapid, potent and selective UPS-dependent degradation of the DYRK1 protein, resulting in effective suppression of the DYRK1 pathway, superior to that observed with classical type 1 DYRK1 inhibitors