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About this article Cite this article Huang, KP., Acosta, A.A., Ghidewon, M.Y

NICE NG28 recommends considering an SGLT2 inhibitor as the preferred option in adults with type 2 diabetes and chronic kidney disease or heart failure, unless contraindicated or not tolerated

Over weeks and months, this adds up to significant muscle loss that is extremely difficult to reverse

When combined, the dual GIP and GLP-1 create synergistic effects leading to greater weight loss and better blood sugar management than GLP-1 alone

doi: 10.1007/s10059-010-0100-5

While B12 is generally safe, using it as a substitute for a prescribed GLP-1 medication means the patient is not receiving the actual treatment they need for weight management or blood sugar control