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Twenty-four weeks after randomization, the DLX + PGB + PEA + ALC group showed additional significant improvements in all outcome measures, demonstrating the effectiveness of adding PEA + ALC therapy to DLX + PGB in FMS patients [33]

Other studies have reported minimal safety concerns regarding short-term supplementation of up to 14 grams per day ( Overall, it is believed that the short-term use of supplements is likely safe

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59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility