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[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Turner S, Diako C, Kruger R, Wong M, Wood W, Rutherfurd-Markwick K, Ali A

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However, under excessive or repetitive strain, calcium overload through TRPV4 and Piezo1 triggers activation of NADPH oxidase (NOX) enzymes and mitochondrial ROS production, leading to oxidative damage, inflammatory gene expression, and cell apoptosis (Swain and Liddle, 2021)