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Small molecule blockade of CD38, therefore, compromises interactions between endogenous substrates (NAD + , NMN) and the active site

This allows the B12 to bypass the digestive system and any malabsorption issues

Storage and handling post-mixing are vital

Proper handling and storage are critical to maintaining its efficacy and safety

As absorption is reduced, body stores become low and a deficiency occurs Underlying diseases most commonly include: IBD (inflammatory bowel disease) Intestinal cancer (especially small cell lymphoma) Liver disease Pancreatitis and other pancreatic diseases Symptoms of low B12 levels Typically found in middle-aged or older cats that present with: Weight loss Diarrhea Vomiting Anorexia Thickened intestines In humans, B12 deficiency may also be associated with dementia, cardiovascular disease, and a certain type of anemia, although these are not specifically recognized problems in cats

Doctors can reduce doses, increase intervals, or change ingredients to ensure safety