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This evidence was strengthened by studies in vivo in which manipulation of calpastatin levels, an endogenous calpain inhibitor, led to modulation of the neurological phenotype seen in a SCA3 mouse model, as well as of mutant ATXN3 aggregation and neurodegeneration, consistent with a role for calpain activation in pathogenesis [50, 52]

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Not as a replacement for proper diagnosis or rehabilitation

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Cutting K.F., White R.J., Mahoney P
References View all references + Sikiri, P., et al

The IV protocol can change based on the situation
