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Side Effects: What You Need to Know Hydroquinone Side Effects Hydroquinone misuse or prolonged use can lead to: Chronic irritation Uneven whitening or patchiness Thinning of the skin Rebound darkness after stopping Exogenous ochronosis (rare but serious bluish-black discoloration) These risks increase when hydroquinone is: Used without medical supervision Applied longer than recommended Combined with sun exposure Mixed with steroid creams Alpha Arbutin Side Effects Alpha arbutin is considered one of the safest brightening agents available

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however, time in remission is not very long

Additionally, some evidence suggests that B12 deficiency can increase the risk of developing diabetes

Neuropsychobiology, 9 (4), 197-206