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The GI symptoms of abdominal pain, gas, diarrhea, and constipation are associated with a greater risk for worsened ASD symptoms including withdrawal, irritability, and hyperactivity [38]

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, Weng, S.W

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Mitochondrial-derived non-coding RNAs (ncRNAs) also fall under the retrograde signaling umbrella (Zhang et al., 2019)

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