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Study Highlights: - Participants received cryoneurolysis to the sciatic, femoral, obturator, and lateral femoral cutaneous nerves

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This HTS protocol seems biased to detect compounds targeting aggregated structures rather than monomeric proteins, which represents a clear advantage for its potential therapeutic use since they would only target pathological -Syn assemblies without interfering with the activity of the soluble and functional protein

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doi: 10.1097/00001756-199906030-00032