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The follow-up that matters for this specific compound landed in 2018, when a small-molecule NNMT inhibitor was given to obese mice

Clinical research published in Biochemical Pharmacology demonstrates that 5 amino 1mq treatment significantly reduces NNMT activity in adipocytes, leading to increased intracellular NAD+ concentrations

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Improved nutrient levels: Addressing a B12 deficiency could indirectly improve overall health

This distinguishes 5-amino-1mq from compounds like cagrilintide or tirzepatide that work primarily through appetite suppression

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