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Therapeutic interventions that target the IGF axis Due to its central role in IGF signaling, the IGF-1R has been studied as a target for therapeutic interventions using several strategies that were developed for clinical studies, such as anti-IGF-1R antibodies, IGF-1/2 neutralizing antibodies, nucleic acid-based approaches, small molecule tyrosine kinase inhibitors (TKIs), and IGF ligand TRAPs

However other solutes in the sample will tend to be washed off or eluted from the column as nonretained compounds

Cell Host Microbe 15 , 374381 (2014)

Moreover, immune cellspecific transcriptomic or proteomic dataparticularly from rare tumor subtypes or treatment-resistant populationsare often underrepresented, making it difficult to stratify patient response to novel small-molecule immunotherapies