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Both are antioxidants that can work synergistically to enhance each other's effects

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p53 is associated with the two key kinases of ataxia telangiectasia and rad3-related protein-checkpoint kinase 1 pathway [45] that induce the transcription of cell cycle suppressor p21 gene and delay damaged G1 cells from entering S phase, preventing new start events at the beginning of the duplication process and slowing down the branching processes of reproduction of UV-irradiated cells in the S phase

The two ingredients work together to help lighten the skin, without leaving behind too many undesirable side effects or long-term health problems