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By selectively targeting L-type calcium channels, amlodipine stabilizes the influx of calcium ions, which is a critical component for muscle contraction processes within these cells

doi: 10.1016/j.devcel.2010.01.016

Interestingly, as desensitization involves a number of steps including receptor phosphorylation, -Arr recruitment, and internalization or degradation, aberrations at any level may precipitate disease

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