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10.1007/s11356-018-2522-0 11 Cano-ViverosS.Galar-MartnezM.Gasca-PrezE.Garca-MedinaS.Ruiz-LaraK.Gmez-OlivnL

This epigenetic alteration can persist long after alcohol consumption has ceased, leading to long-term deficits in BDNF levels and associated depressive symptoms

[DOI] [PubMed] [Google Scholar] [53].Mendieta-Serrano MA, Schnabel D, Lomeli H, et al

Choueiri TK, Bauer TM, McDermott DF, Arrowsmith E, Roy A, Perini RF, et al

Reduced glutathione achieves this by attenuating ROS, which is important in the context of inflammation because ROS stimulates the activity of these proinflammatory cytokines

The type 1 site, which was also predicted by ZincBind appears to be the strongest and most important, and its occupancy seems to affect the properties of PEDF at low zinc concentrations (see Fig