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Epigenetic regulation of cancer stem cells: shedding light on the refractory/relapsed cancers

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Wnt induction of Axin2, Dkk1 and Naked and suppression of Fz and LRP6 constitute negative feedback loops that dampen Wnt signaling, and the suppression of Fz and LRP6 also enhances Wg/Wnt gradient formation over longer distances (Logan and Nusse, 2004)

They showed a significant decrease in the expression of FSH receptor, activin, and androgen receptor genes as the DZN concentration increased

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