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Chronic sleep deprivation and elevated stress increase cortisol, promote insulin resistance, stimulate appetite (partially overriding semaglutide), and preferentially promote fat storage in the abdominal area

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These results also showed that it does not affect the dysregulation of cellular gene splicing, ruling out its potential genotoxic effects [120]

[DOI] [PubMed] [Google Scholar] 50.Kang E.A., Han Y.M., An J.M., Park Y.J., Sikiric P., Kim D.H., Kwon K.A., Kim Y.J., Yang D., Tchah H., et al

In Parkinsons disease, curcumin inhibits DNMTs, leading to demethylation and reactivation of neuroprotective genes like Nurr1, DJ-1, and PARK genes, and acts as an HDAC inhibitor to enhance histone acetylation, promoting transcription of genes involved in neuronal survival and synaptic plasticity