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Cyto-roGFP2-Orp1 biosensor, expressed in motor neurons, reflects the kinetics of H 2 O 2 neutralization To assess the dynamic response of the MNs expressing Cyto-roGFP2-Orp1 and Mito-roGFP2-Orp1 biosensors to oxidation, we first determined the concentration of H 2 O 2 that did not affect MN viability in the culture

The relationship between ROS production and proinflammatory cytokine activation is well established [22]

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Author Contributions Conceived and designed the experiments: SKC DMG GSM JL LB

4345 Lysosomal-dependent cell death (LDCD) is a cell death pathway triggered by LMP