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Activated Caspase-11/4/5 can cleave GSDMD proteins and activate NLRP3 inflammasome, leading to the release of inflammatory cytokines (IL-1/-18) and cell death, independent of Caspase-1

Regulatory note: 5-Amino-1MQ is not FDA-approved for any use and has not been studied in completed human clinical trials

2025;145:29892997.e7

Binding of two zinc ions promotes liquid-liquid phase separation of Tau

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