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Due to their extensive use and a high degree of resistance to degradation, they accumulate in the environment over prolonged periods, potentially several centuries, and are now recognised as one of the major global pollutants [1]

These SPP1 + macrophages drive fibrosis by secreting their encoded protein, osteopontin (OPN), which interacts with CD44/integrin receptors on stromal progenitor cells, such as fibro-adipogenic progenitors (FAPs), thereby promoting their differentiation into matrix-producing fibroblasts (185)

Shi et al., 2016)

Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations ABCD1: ATP-binding cassette protein subfamily D ACALD: Adult cerebral form AD: Alzheimers disease AdolCALD: Adolescent cerebral form AMN: Adrenomyeloneuropathy BBB: Blood-brain barrier BMDM: Bone marrow-derived macrophages CBT: Cord blood transplantation CCALD: Childhood cerebral form CNS: Central nervous system ELOVL: Elongation of very long chain fatty acid HSCT: Hematopoietic stem cell transplantation MD: Multiple sclerosis MRI: Magnetic resonance imaging PBD: Peroxisome biogenesis disorder PD: Parkinsons disease ROS: Reactive oxygen species VLCFA: Very long chain fatty acid X-ALD: X-Linked adrenoleukodystrophy References Asheuer M et al (2004) Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein

While we still remove a significant portion of the pelvic bone, the leg can often be saved

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