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When, however, the level of ROS overwhelms these cellular defenses, the cell will sustain damage (in a dose-dependent manner) that can lead to carcinogenesis, teratogenesis, necrosis, or apoptosis (Fig

Usui S, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA

From Contraindication to Consolidation: Surgery After Pleural Response in Stage IV NSCLC

doi: 10.1146/annurev-nutr-071714-034228

Cummings DE, Foster-Schubert KE, Overduin J