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Many preclinical studies have indicated that Ea exhibits neuroprotective effects by anti-apoptosis and reduction of neuroinflammation, mediated by the p38 MAPK pathway, TLR4/NF-B pathway, and PI3K/Akt pathway [9599]

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But it may respond to I/R injury in cardiomyocytes

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95% CI, 0.58-0.88) (100)

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Patients reporting fatigue, cold intolerance, or cognitive slowing while on KDdespite normal TSHshould be assessed for potential functional hypothyroidism and evaluated for nutritional adequacy, particularly regarding selenium, iodine, and zinc status, all of which are essential for optimal thyroid hormone synthesis and conversion [116]

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Improper storage conditions, such as extended exposure to direct sunlight, high heat & humidity, can cause product degradation over time.

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