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Antioxidants 9(11):1147

439 Most importantly, clarifying the concept of the hematopoietic niche, which refers to the spatial localization and unique microenvironment of HSCs and immune cells within the bone marrow, is essential

Peptide P3143 accumulation in lysosomes leads to activation of some signal transduction pathways and to increased levels of free radicals (reactive oxygen species, ROS and reactive nitrogen species, RNS) [28] (Figure 1 and Figure 2)

Second, Nrf2 upregulation increases cell proliferation and this is accompanied by hyperphosphorylation of retinoblastoma protein, possibly brought about by increased activity of the cyclin D1/CDK4/CDK6 complex and the cyclin E/CDK2 complex that has been speculated to be a consequence of repression of p21 expression [420]