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This provides a unique, quantifiable biomarker of target engagement, making NSI-189 phosphate the compound of choice for studies focused on structural neural plasticity and hippocampal-dependent cognitive recovery

The results of these two behavioral tests showed that H1d and H3d mice did not experience cognitive decline, while H7d and H14d mice showed a significant weakening in novel object recognition and impaired spatial memory abilities (Fig

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The toxicity profile was acceptable: the most common severe AEs were hypertension, decreased platelet count and hand-foot syndrome