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These results are accompanied by a consistent effect on the mRNA expression of several genes ( Vegfr2, Src, Nos2, Nos1, Nos3, Akt1, Kras, Mapk1, Srf, Foxo1, Nfkb1, and Egr1 )

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Therefore, scientific evidence highlights the importance of early oxidative stress in the CIPN onset

In addition, combination therapies such as co-administration with glycyrrhizic acid ( Nanotechnology-based TPL The clinical application of TPL is limited by several factors including its significant systemic toxicity and poor water solubility

i , Autochthonous tumors from MMTV-PyMT Gclcf/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into the mammary gland or subcutaneously transplanted into the flank of wild-type C57BL/6 mice, which were treated with vehicle (corn oil