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also known as xCT) and the selenium-dependent hydroperoxidase glutathione peroxidase 4 (GPX4) are the most potent antioxidant hubs protecting against ferroptosis [35, 36], with the cystine/glutamate antiporter subunit SLC7A11 importing cysteine to synthesize glutathione (GSH), a critical cofactor to multiple antioxidant proteins, including GPX4, thereby detoxifying lipid peroxides and suppressing ferroptosis [33, 37]

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